Mithridatism for dementia? Hypoxic - Hyperoxic training in dementia
Introduction: Intense research on dementia has been conducted during the last years. As advances in the field have started changing the landscape of dementia treatment, it is necessary to assess the impact of novel therapeutic modalities.
Purpose: The current evidence about hypoxic – hyperoxic treatment for dementia is reviewed in this article.
Methods: We conducted a thorough PubMed/MEDLINE and Google Scholar search.
Results: Preclinical and clinical data are available. Hypoxic – hyperoxic treatment is encouraged in the context of the multimodal treatment of dementia. There are concerns about the recovery of memory with regard to specific modalities of this treatment. Future perspectives are highlighted in the light of potentially useful biomarkers and health policy.
Conclusion: While constant updates and further research is critical to understand the impact of hypoxic – hyperoxic treatment in dementia, the available studies are limited and, hence, research that is more extensive is necessary. Currently, it is important to assess the current state of knowledge highlighting the success but also the stalemates of this treatment
Bayer, U., Glazachev, O. S., Likar, R., Burtscher, M., Kofler, W., Pinter, G., Stettner, H., Demschar, S., Trummer, B., & Neuwersch, S. (2017). Adaptation to intermittent hypoxia-hyperoxia improves cognitive performance and exercise tolerance in elderly. Advances in Gerontology = Uspekhi Gerontologii. https://doi.org/10.5281/zenodo.1997725
Bayer, Urike, Likar, R., Pinter, G., Stettner, H., Demschar, S., Trummer, B., Neuwersch, S., Glazachev, O., & Burtscher, M. (2017). Intermittent hypoxic–hyperoxic training on cognitive performance in geriatric patients. Alzheimer’s and Dementia: Translational Research and Clinical Interventions. https://doi.org/10.1016/j.trci.2017.01.002
Chavez, J. C., Agani, F., Pichiule, P., & LaManna, J. C. (2000). Expression of hypoxia-inducible factor-1α in the brain of rats during chronic hypoxia. Journal of Applied Physiology. https://doi.org/10.1152/jappl.2000.89.5.1937
CIRRITO, J. R., & HOLTZMAN, D. M. (2008). ANTI-AMYLOID-β IMMUNOTHERAPY AS A TREATMENT FOR ALZHEIMER’S DISEASE. In CNS Regeneration (pp. 295–318). Elsevier. https://doi.org/10.1016/B978-012373994-0.50014-2
Gao, B., Long, Z., Zhao, L., & He, G. (2011). Effect of normobaric hyperoxia on behavioral deficits and neuropathology in alzheimer’s disease mouse model. Journal of Alzheimer’s Disease. https://doi.org/10.3233/JAD-2011-110308
Hugo, J., & Ganguli, M. (2014). Dementia and Cognitive Impairment. Epidemiology, Diagnosis, and Treatment. In Clinics in Geriatric Medicine. https://doi.org/10.1016/j.cger.2014.04.001
Lall, R., Mohammed, R., & Ojha, U. (2019). What are the links between hypoxia and alzheimer’s disease? In Neuropsychiatric Disease and Treatment. https://doi.org/10.2147/NDT.S203103
Macri, M. A., D’Alessandro, N., Di Giulio, C., Di Iorio, P., Di Luzio, S., Giuliani, P., Esposito, E., & Pokorski, M. (2010). Region-specific effects on brain metabolites of hypoxia and hyperoxia overlaid on cerebral ischemia in young and old rats: a quantitative proton magnetic resonance spectroscopy study. Journal of Biomedical Science. https://doi.org/10.1186/1423-0127-17-14
Malle, C., Bourrilhon, C., Pierard, C., Quinette, P., Laisney, M., & Eustache, F. (2016). Physiological and Cognitive Effects of Acute Normobaric Hypoxia and Modulations from Oxygen Breathing. Aerospace Medicine and Human Performance. https://doi.org/10.3357/AMHP.4335.2016
Manukhina, E. B., Downey, H. F., Shi, X., & Mallet, R. T. (2016). Intermittent hypoxia training protects cerebrovascular function in Alzheimer’s disease. Experimental Biology and Medicine. https://doi.org/10.1177/1535370216649060
Murphy, S. L., Xu, J., & Kochanek, K. D. (2013). Deaths: final data for 2010. National Vital Statistics Reports : From the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System, 61(4), 1–117. https://pubmed.ncbi.nlm.nih.gov/24979972/
Pichiule, P., & Lamanna, J. C. (2002). Angiopoietin-2 and rat brain capillary remodeling during adaptation and deadaptation to prolonged mild hypoxia. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.00318.2002
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013). The global prevalence of dementia: A systematic review and metaanalysis. In Alzheimer’s and Dementia. https://doi.org/10.1016/j.jalz.2012.11.007
Serebrovska, Z. O., Serebrovska, T. V., Kholin, V. A., Tumanovska, L. V., Shysh, A. M., Pashevin, D. A., Goncharov, S. V., Stroy, D., Grib, O. N., Shatylo, V. B., Bachinskaya, N. Y., Egorov, E., Xi, L., & Dosenko, V. E. (2019). Intermittent hypoxia-hyperoxia training improves cognitive function and decreases circulating biomarkers of Alzheimer’s disease in patients with mild cognitive impairment: A pilot study. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms20215405
Valle, G., Carmignani, M., Stanislao, M., Facciorusso, A., & Volpe, A. R. (2017). Mithridates VI eupator king of pontus and the venomous snakes. In Central European Journal of Urology. https://doi.org/10.5173/ceju.2017.1479
Watanabe, T., Tan, Z., Wang, X., Martinez-Hernandez, A., & Frahm, J. (2019). Magnetic resonance imaging of noradrenergic neurons. Brain Structure and Function. https://doi.org/10.1007/s00429-019-01858-0